Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation

Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation

Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway, including asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP). Distinct MC subsets infiltrate the airway mucosa in T2 disease, including subepithelial MCs expressing the proteases tryp...

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Main Authors: Dwyer, Daniel F (Author), Ordovas-Montanes, Jose (Author), Allon, Samuel J (Author), Buchheit, Kathleen M (Author), Vukovic, Marko (Author), Derakhshan, Tahereh (Author), Feng, Chunli (Author), Lai, Juying (Author), Hughes, Travis K (Author), Nyquist, Sarah K (Author), Giannetti, Matthew P (Author), Berger, Bonnie (Author), Bhattacharyya, Neil (Author), Roditi, Rachel E (Author), Katz, Howard R (Author), Nawijn, Martijn C (Author), Berg, Marijn (Author), van den Berge, Maarten (Author), Laidlaw, Tanya M (Author), Shalek, Alex K (Author), Barrett, Nora A (Author), Boyce, Joshua A (Author)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2022-03-18T15:07:08Z.
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