CRISPR/Cas9 editing to generate a heterozygous COL2A1 p.G1170S human chondrodysplasia iPSC line, MCRIi019-A-2, in a control iPSC line, MCRIi019-A

CRISPR/Cas9 editing to generate a heterozygous COL2A1 p.G1170S human chondrodysplasia iPSC line, MCRIi019-A-2, in a control iPSC line, MCRIi019-A

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© 2020 To develop an in vitro disease model of a human chondrodysplasia, we used CRISPR/Cas9 gene editing to generate a heterozygous COL2A1 exon 50 c.3508 GGT > TCA (p.G1170S) mutation in a control human iPSC line. Both the control and COL2A1 mutant lines displayed typical iPSC characteristics, i...

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Bibliographic Details
Main Authors:	Kung, Louise HW (Author), Sampurno, Lisa (Author), Yammine, Kathryn M (Author), Graham, Alison (Author), McDonald, Penny (Author), Bateman, John F (Author), Shoulders, Matthew D (Author), Lamandé, Shireen R (Author)
Format:	Article
Language:	English
Published:	Elsevier BV, 2022-03-18T18:50:29Z.
Subjects:	Article
Online Access:	Get fulltext

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