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|a Mescher, Mark J.
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|a Massachusetts Institute of Technology. Department of Mechanical Engineering
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|a McKenna, Michael J.
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|a Swan, Erin Leary
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|a Swan, Erin Leary
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|a Fiering, Jason
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|a Holmboe, Maria E.
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|a Sewell, William F.
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|a Kujawa, Sharon G.
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|a McKenna, Michael J.
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|a Borenstein, Jeffrey T.
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|a Fabrication methods and performance of low-permeability microfluidic components for a miniaturized wearable drug delivery system
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|b Institute of Electrical and Electronics Engineers,
|c 2010-11-08T14:09:12Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/59852
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|a In this paper, we describe low-permeability components of a microfluidic drug delivery system fabricated with versatile micromilling and lamination techniques. The fabrication process uses laminate sheets which are machined using XY milling tables commonly used in the printed-circuit industry. This adaptable platform for polymer microfluidics readily accommodates integration with silicon-based sensors, printed-circuit, and surface-mount technologies. We have used these methods to build components used in a wearable liquid-drug delivery system for in vivo studies. The design, fabrication, and performance of membrane-based fluidic capacitors and manual screw valves provide detailed examples of the capability and limitations of the fabrication method. We demonstrate fluidic capacitances ranging from 0.015 to 0.15 muL/kPa, screw valves with on/off flow ratios greater than 38000, and a 45times reduction in the aqueous fluid loss rate to the ambient due to permeation through a silicone diaphragm layer.
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|a National Institute of Deafness and other Communication Disorders (U.S.) (NIDCD) (Grant 5 R01 DC 006848-02)
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|a en_US
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|a Article
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|t Journal of Microelectromechanical Systems
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