Structural Basis of Low-Affinity Nickel Binding to the Nickel-Responsive Transcription Factor NikR from Escherichia coli
Escherichia coli NikR regulates cellular nickel uptake by binding to the nik operon in the presence of nickel and blocking transcription of genes encoding the nickel uptake transporter. NikR has two binding affinities for the nik operon: a nanomolar dissociation constant with stoichiometric nickel a...
Main Authors: | Phillips, Christine M. (Contributor), Schreiter, Eric R. (Contributor), Stultz, Collin M. (Contributor), Drennan, Catherine L. (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Research Laboratory of Electronics (Contributor) |
Format: | Article |
Language: | English |
Published: |
American Chemical Society,
2011-06-30T15:12:00Z.
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Subjects: | |
Online Access: | Get fulltext |
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