Recognition of Platinum−DNA Damage by Poly(ADP-ribose) Polymerase-1

Recognition of Platinum−DNA Damage by Poly(ADP-ribose) Polymerase-1

Poly(ADP-ribose) polymerase-1 (PARP-1) was recently identified as a platinum−DNA damage response protein. To investigate the properties of binding of PARP-1 to different platinum−DNA adducts in greater detail, biotinylated DNA probes containing a site-specific cisplatin 1,2-d(GpG) or 1,3-d(GpTpG) in...

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Bibliographic Details
Main Authors: Zhu, Guangyu (Contributor), Chang, Paul (Contributor), Lippard, Stephen J. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Chemical Society, 2011-07-07T14:34:10Z.
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