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65145 |
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|a dc
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|a Tang, Chenkang
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|a Massachusetts Institute of Technology. Center for Biomedical Engineering
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|a Zhao, Xiaojun
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|a Zhao, Xiaojun
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|a Shao, Ximing
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|a Sun, Binbin
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|a Huang, Wenli
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|a Zhao, Xiaojun
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|a The Effect of Self-Assembling Peptide RADA16-I on the Growth of Human Leukemia Cells in Vitro and in Nude Mice
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|b Molecular Diversity Preservation International,
|c 2011-08-15T17:44:36Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/65145
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|a Nanofiber scaffolds formed by self-assembling peptide RADA16-I have been used for the study of cell proliferation to mimic an extracellular matrix. In this study, we investigated the effect of RADA16-I on the growth of human leukemia cells in vitro and in nude mice. Self-assembly assessment showed that RADA16-I molecules have excellent self-assembling ability to form stable nanofibers. MTT assay displayed that RADA16-I has no cytotoxicity for leukemia cells and human umbilical vein endothelial cells (HUVECs) in vitro. However, RADA16-I inhibited the growth of K562 tumors in nude mice. Furthermore, we found RADA16-I inhibited vascular tube-formation by HUVECs in vitro. Our data suggested that nanofiber scaffolds formed by RADA16-I could change tumor microenvironments, and inhibit the growth of tumors. The study helps to encourage further design of self-assembling systems for cancer therapy.
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|a China. Ministry of Education (project 985)
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|a en_US
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|a Article
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|t International Journal of Molecular Sciences
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