A Yeast Model of FUS/TLS-Dependent Cytotoxicity

A Yeast Model of FUS/TLS-Dependent Cytotoxicity

FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant forms of FUS/TLS traffic to, and form inclusions in, the cytoplasm of affected s...

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Main Authors: Ju, Shulin (Author), Tardiff, Daniel F. (Contributor), Han, Haesun (Contributor), Divya, Kanneganti (Author), Zhong, Quan (Author), Maquat, Lynne E. (Author), Bosco, Daryl A. (Author), Hayward, Lawrence J. (Author), Brown, Robert H. (Author), Lindquist, Susan (Contributor), Ringe, Dagmar (Author), Petsko, Gregory A. (Author)
Other Authors: move to dc.description.sponsorship (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2011-08-31T19:58:32Z.
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