Adult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilage
Objective: To quantify the structural characteristics and nanomechanical properties of aggrecan produced by adult bone marrow stromal cells (BMSCs) in peptide hydrogel scaffolds and compare to aggrecan from adult articular cartilage. Design: Adult equine BMSCs were encapsulated in 3D-peptide hydroge...
Main Authors: | Lee, H.-Y (Contributor), Kopesky, Paul Wayne (Contributor), Plaas, A. (Author), Sandy, J. (Author), Kisiday, John D. (Contributor), Frisbie, David D. (Author), Grodzinsky, Alan J. (Contributor), Ortiz, Christine (Contributor) |
---|---|
Other Authors: | Massachusetts Institute of Technology. Center for Biomedical Engineering (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor) |
Format: | Article |
Language: | English |
Published: |
Elsevier Ltd.,
2011-11-21T22:30:12Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Ultrastructure and nanomechanical properties of aggrecan from native cartilage and engineered tissue
by: Lee, Hsu-Yi
Published: (2010) -
Adult equine bone-marrow stromal cells produce a cartilage-like ECM superior to animal-matched adult chondrocytes
by: Kisiday, John D., et al.
Published: (2011) -
Probing nanomechanics of aggrecan and the aggrecan-rich pericellular matrix of chondrocytes in cartilage
by: Ng, Laurel Jean
Published: (2006) -
Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains
by: Lee, Hsu-Yi, et al.
Published: (2015) -
Controlled Delivery of Transforming Growth Factor β1 by Self-Assembling Peptide Hydrogels Induces Chondrogenesis of Bone Marrow Stromal Cells and Modulates Smad2/3 Signaling
by: Kopesky, Paul Wayne, et al.
Published: (2011)