Normal and neoplastic non-stem cells can spontaneously convert to a stem-like state

Normal and neoplastic non-stem cells can spontaneously convert to a stem-like state

Current models of stem cell biology assume that normal and neoplastic stem cells reside at the apices of hierarchies and differentiate into nonstem progeny in a unidirectional manner. Here we identify a subpopulation of basal-like human mammary epithelial cells that departs from that assumption, spo...

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Main Authors: Su, Ying (Author), Polyak, Kornelia (Author), Arendt, Lisa M. (Author), Kuperwasser, Charlotte (Author), Bierie, Brian (Author), Chaffer, Christine L. (Contributor), Brueckmann, Ines (Contributor), Scheel, Christina (Contributor), Kaestli, Alicia J. (Contributor), Wiggins, Paul A. (Contributor), Rodrigues, Leonardo O. (Contributor), Brooks, Mary (Contributor), Reinhardt, Ferenc (Contributor), Weinberg, Robert A (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Ludwig Center for Molecular Oncology (Massachusetts Institute of Technology) (Contributor), Weinberg, Robert A. (Contributor)
Format: Article
Language:English
Published: New York Academy of Sciences, 2011-12-02T20:04:25Z.
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