Mechanism of the Very Efficient Quenching of Tryptophan Fluorescence in Human γD- and γS-Crystallins: The γ-Crystallin Fold May Have Evolved To Protect Tryptophan Residues from Ultraviolet Photodamage
Proteins exposed to UV radiation are subject to irreversible photodamage through covalent modification of tryptophans (Trps) and other UV-absorbing amino acids. Crystallins, the major protein components of the vertebrate eye lens that maintain lens transparency, are exposed to ambient UV radiation t...
Main Authors: | Callis, Patrik R. (Author), King, Jonathan Alan (Contributor), Chen, Jiejin, Ph. D. Massachusetts Institute of Technology (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Chen, Jiejin (Contributor) |
Format: | Article |
Language: | English |
Published: |
American Chemical Society (ACS),
2012-09-26T13:28:00Z.
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Subjects: | |
Online Access: | Get fulltext |
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