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02567 am a22003853u 4500 |
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73451 |
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|a dc
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|a Irvine, Darrell J.
|e author
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|a MIT Materials Research Laboratory
|e contributor
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|a Lincoln Laboratory
|e contributor
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|a Massachusetts Institute of Technology. Department of Biological Engineering
|e contributor
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|a Massachusetts Institute of Technology. Department of Chemical Engineering
|e contributor
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|a Massachusetts Institute of Technology. Department of Materials Science and Engineering
|e contributor
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|a Irvine, Darrell J.
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|a Cohen, Robert E.
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|a Rubner, Michael F.
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|a Gilbert, Jonathan Brian
|e contributor
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|a Swiston, Albert J., Jr.
|e contributor
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|a Cohen, Robert E.
|e author
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|a Rubner, Michael F.
|e author
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|a Gilbert, Jonathan Brian
|e author
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|a Swiston, Albert J., Jr.
|e author
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|a Freely Suspended Cellular "Backpacks" Lead to Cell Aggregate Self-Assembly
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|b American Chemical Society (ACS),
|c 2012-09-27T20:42:01Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/73451
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|a Cellular "backpacks" are a new type of anisotropic, nanoscale thickness microparticle that may be attached to the surface of living cells creating a "bio-hybrid" material. Previous work has shown that these backpacks do not impair cell viability or native functions such as migration in a B and T cell line, respectively. In the current work, we show that backpacks, when added to a cell suspension, assemble cells into aggregates of reproducible size. We investigate the efficiency of backpack−cell binding using flow cytometry and laser diffraction, examine the influence of backpack diameter on aggregate size, and show that even when cell−backpack complexes are forced through small pores, backpacks are not removed from the surfaces of cells.
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|a National Science Foundation (U.S.). Materials Research Science and Engineering Centers (Program) (Award DMR-08-19762)
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|a National Science Foundation (U.S.) (Graduate Research Fellowship)
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|a United States. Dept. of Defense
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|a United States. Air Force Office of Scientific Research
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|a Howard Hughes Medical Institute (Investigator)
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|a United States. Dept. of Defense (National Defense Science and Engineering Graduate Fellowship 32 CFR 168a)
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|a en_US
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|a Article
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|t Biomacromolecules
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