Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA Glycosylase
To efficiently repair DNA, human alkyladenine DNA glycosylase (AAG) must search the million-fold excess of unmodified DNA bases to find a handful of DNA lesions. Such a search can be facilitated by the ability of glycosylases, like AAG, to interact with DNA using two affinities: a lower-affinity int...
Main Authors: | , , , , |
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Other Authors: | , , , , |
Format: | Article |
Language: | English |
Published: |
American Chemical Society,
2012-10-04T13:40:24Z.
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Subjects: | |
Online Access: | Get fulltext |