mTOR and cancer: many loops in one pathway

• Main Authors: Efeyan, Alejo (Contributor), Sabatini, David (Author)
• Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
• Format: Article
• Language: English
• Published: Elsevier, 2012-11-01T16:42:06Z.
• Subjects: Article
• Online Access: Get fulltext

The mammalian target of rapamycin (mTOR) is a master regulator of cell growth and division that responds to a variety of stimuli, including nutrient, energy, and growth factors. In the last years, a significant number of pieces have been added to the puzzle of how mTOR coordinates and executes its functions. Extensive research on mTOR has also uncovered a complex network of regulatory loops that impact the therapeutic approaches aimed at targeting mTOR.
Howard Hughes Medical Institute
National Institutes of Health (U.S.)
Human Frontier Science Program (Strasbourg, France)