Intra-articular Injection of HB-IGF-1 Sustains Delivery of IGF-1 to Cartilage through Binding to Chondroitin Sulfate

Intra-articular Injection of HB-IGF-1 Sustains Delivery of IGF-1 to Cartilage through Binding to Chondroitin Sulfate

Objective: Insulin-like growth factor 1 (IGF-1) stimulates cartilage repair but is not a practical therapy due to its short half-life. We have previously modified IGF-1 by adding a heparin-binding domain and have shown that this fusion protein (HB-IGF-1) stimulates sustained proteoglycan synthesis i...

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Bibliographic Details
Main Authors: Miller, Rachel Elizabeth (Contributor), Grodzinsky, Alan J. (Contributor), Cummings, Kiersten (Author), Plaas, Anna H. K. (Author), Cole, Ada A. (Author), Lee, Richard T. (Author), Patwari, Parth (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2013-01-10T21:20:10Z.
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