Genome-Wide Association Analysis Identifies a Mutation in the Thiamine Transporter 2 (SLC19A3) Gene Associated with Alaskan Husky Encephalopathy
Alaskan Husky Encephalopathy (AHE) has been previously proposed as a mitochondrial encephalopathy based on neuropathological similarities with human Leigh Syndrome (LS). We studied 11 Alaskan Husky dogs with AHE, but found no abnormalities in respiratory chain enzyme activities in muscle and liver,...
Main Authors: | Runstadler, Jonathan (Contributor), Vernau, Karen M. (Author), Brown, Emily A. (Author), Cameron, Jessie M. (Author), Huson, Heather J. (Author), Higgins, Robert J. (Author), Ackerley, Cameron (Author), Sturges, Beverly K. (Author), Dickinson, Peter J. (Author), Puschner, Birgit (Author), Giulivi, Cecilia (Author), Shelton, G. Diane (Author), Robinson, Brian H. (Author), DiMauro, Salvatore (Author), Bollen, Andrew W. (Author), Bannasch, Danika L. (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering (Contributor) |
Format: | Article |
Language: | English |
Published: |
Public Library of Science,
2013-04-26T15:13:07Z.
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Subjects: | |
Online Access: | Get fulltext |
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