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|a Del Vecchio, Domitilla
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|a Massachusetts Institute of Technology. Department of Mechanical Engineering
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|a Del Vecchio, Domitilla
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|a The effect of retroactivity on the transfer function of a phosphorylation system
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|b Institute of Electrical and Electronics Engineers,
|c 2013-04-26T15:35:16Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/78618
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|a It was theoretically shown that impedance-like effects, called retroactivity, in biomolecular circuits can significantly impact the behavior of a system. In this paper, we quantify the effect of retroactivity on the transfer function of a phosphorylation system after linearization of its nonlinear model about a steady state. Our analysis shows that retroactivity shifts the poles of the transfer function toward the low frequency.
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|a Article
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|t Proceedings of the 49th IEEE Conference on Decision and Control (CDC), 2010
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