Fragile X mental retardation protein and synaptic plasticity

Fragile X mental retardation protein and synaptic plasticity

Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a trans...

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Bibliographic Details
Main Authors: Sidorov, Michael Samuel (Contributor), Auerbach, Benjamin David (Contributor), Bear, Mark (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: BioMed Central Ltd, 2013-04-30T19:40:57Z.
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Summary:Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.

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