Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels

• Main Authors: Rhee, Minsoung (Contributor), Valencia, Pedro Miguel (Contributor), Rodriguez, Maria I. (Contributor), Langer, Robert (Contributor), Farokhzad, Omid C. (Author), Karnik, Rohit (Contributor)
• Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
• Format: Article
• Language: English
• Published: Wiley Blackwell, 2013-05-13T18:22:33Z.
• Subjects: Article
• Online Access: Get fulltext

Author Manuscript date: 2011 June 27
A versatile microfluidic platform to synthesize NPs by nanoprecipitation using 3D hydrodynamic flow focusing isolates the precipitating precursors from channel walls, eliminating fouling of the channels. It is shown that this new method enables robust nanoprecipitation without polymer aggregation, regardless of the polymer molecular weight or precursor concentration implemented, where the size of the resulting polymeric NPs is tunable.
David H. Koch (Prostate Cancer Foundation Award in Nanotherapeutics)
National Institutes of Health (U.S.) (Grant CA119349)
National Science Foundation (U.S.) (Graduate Research Fellowship)