Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging

• Main Authors: Mieszawska, Aneta J. (Author), Gianella, Anita (Author), Cormode, David P. (Author), Zhao, Yiming (Author), Meijerink, Andries (Author), Langer, Robert (Contributor), Farokhzad, Omid C. (Author), Fayad, Zahi A. (Author), Mulder, Willem J. M. (Author)
• Other Authors: delete (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
• Format: Article
• Language: English
• Published: Royal Society of Chemistry, 2013-07-09T21:01:11Z.
• Subjects: Article
• Online Access: Get fulltext

Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles that incorporate high payloads of nanocrystals into their core for tunable bioimaging features. We accomplished this through esterification reactions of PLGA to generate polymers modified with nanocrystals. The PLGA nanoparticles formed from modified PLGA polymers that were functionalized with either gold nanocrystals or quantum dots exhibited favorable features for computed tomography and optical imaging, respectively.
National Heart, Lung, and Blood Institute (Programs of Excellence in Nanotechnology (PEN) Award, Contract #HHSN268201000045C))
National Institutes of Health (U.S.) (R01 EB009638)
National Institutes of Health (U.S.) (R01 CA155432)
National Institutes of Health (U.S.) (K99 EB012165)
Netherlands Organization for Scientific Research ((NWO) ECHO.06.B.047)