3-Dimensional Multiwaveguide Probe Array for Light Delivery to Distributed Brain Circuits

2013 February 14, Author Manuscript

Bibliographic Details
Main Authors: Zorzos, Anthony Nicholas (Contributor), Scholvin, Jorg (Contributor), Fonstad, Clifton G., Jr (Contributor), Boyden, Edward (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Media Laboratory (Contributor), Massachusetts Institute of Technology. Microsystems Technology Laboratories (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Program in Media Arts and Sciences (Massachusetts Institute of Technology) (Contributor), Boyden, Edward Stuart (Contributor)
Format: Article
Language:English
Published: Optical Society of America, 2013-08-08T13:56:58Z.
Subjects:
Online Access:Get fulltext
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042 |a dc 
100 1 0 |a Zorzos, Anthony Nicholas  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Biological Engineering  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Media Laboratory  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Microsystems Technology Laboratories  |e contributor 
100 1 0 |a McGovern Institute for Brain Research at MIT  |e contributor 
100 1 0 |a Program in Media Arts and Sciences   |q  (Massachusetts Institute of Technology)   |e contributor 
100 1 0 |a Zorzos, Anthony Nicholas  |e contributor 
100 1 0 |a Scholvin, Jorg  |e contributor 
100 1 0 |a Boyden, Edward Stuart  |e contributor 
100 1 0 |a Fonstad, Clifton G., Jr.  |e contributor 
700 1 0 |a Scholvin, Jorg  |e author 
700 1 0 |a Fonstad, Clifton G., Jr.  |e author 
700 1 0 |a Boyden, Edward  |e author 
245 0 0 |a 3-Dimensional Multiwaveguide Probe Array for Light Delivery to Distributed Brain Circuits 
246 3 3 |a Three-dimensional multiwaveguide probe array for light delivery to distributed brain circuits 
260 |b Optical Society of America,   |c 2013-08-08T13:56:58Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/79800 
520 |a 2013 February 14, Author Manuscript 
520 |a To deliver light to the brain for neuroscientific and neuroengineering applications like optogenetics, in which light is used to activate or silence neurons expressing specific photosensitive proteins, optical fibers are commonly used. However, an optical fiber is limited to delivering light to a single target within the 3D structure of the brain. Here, we describe the design and fabrication of an array of thin microwaveguides, which terminates at a three-dimensionally distributed set of points, appropriate for delivering light to targets distributed in a 3D pattern throughout the brain. 
520 |a Paul G. Allen Family Foundation 
520 |a National Science Foundation (U.S.) (CAREER Award CBET 1053233) 
520 |a New York Stem Cell Foundation. Robertson Neuroscience Investigator Award 
520 |a McGovern Institute for Brain Research at MIT. Neurotechnology (MINT) Program 
520 |a United States. National Institutes of Health (NIH Grant 1R01DA02963) 
520 |a National Science Foundation (U.S.). Graduate Research Fellowship Program 
520 |a McGovern Institute for Brain Research at MIT (Hubert Schoemaker Fellowship) 
520 |a Institution of Engineering and Technology (A. F. Harvey Prize) 
520 |a Massachusetts Institute of Technology. Media Laboratory 
546 |a en_US 
655 7 |a Article 
773 |t Optics Letters