Water-Soluble Narrow-Line Radicals for Dynamic Nuclear Polarization

• Main Authors: Haze, Olesya (Contributor), Smith, Albert A. (Contributor), Corzilius, Bjorn (Contributor), Griffin, Robert Guy (Contributor), Swager, Timothy M (Author)
• Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor), Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology) (Contributor), Swager, Timothy M. (Contributor), Swager, Timothy Manning (Contributor)
• Format: Article
• Language: English
• Published: American Chemical Society (ACS), 2013-08-14T17:01:46Z.
• Subjects: Article
• Online Access: Get fulltext

The synthesis of air-stable, highly water-soluble organic radicals containing a 1,3-bis(diphenylene)-2-phenylallyl (BDPA) core is reported. A sulfonated derivative, SA-BDPA, retains the narrow electron paramagnetic resonance linewidth (<30 MHz at 5 T) of the parent BDPA in highly concentrated glycerol/water solutions (40 mM), which enables its use as polarizing agent for solid effect dynamic nuclear polarization (SE DNP). A sensitivity enhancement of 110 was obtained in high-field magic-angle-spinning (MAS) NMR experiments. The ease of synthesis and high maximum enhancements obtained with the BDPA-based radicals constitute a major advance over the trityl-type narrow-line polarization agents.
National Institutes of Health (U.S.). (Grant GM095843)
National Institutes of Health (U.S.). (Grant EB002804)
National Institutes of Health (U.S.). (Grant EB002026)