Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry

Double-stranded DNA (dsDNA) unconstrained by torsion undergoes an overstretching transition at about 65 pN, elongating the DNA to about 1.7-fold. Three possible structural transitions have been debated for the nature of DNA overstretching: (i) "peeling" apart of dsDNA to produce a peeled s...

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Bibliographic Details
Main Authors: Zhang, Xinghua (Author), Chen, Hu (Author), Le, Shimin (Author), Rouzina, Ioulia (Author), Doyle, Patrick S. (Contributor), Yan, Jie (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2013-09-11T16:49:13Z.
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