Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection

Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection

Covalently conjugating multiple copies of the drug zanamivir (ZA; the active ingredient in Relenza) via a flexible linker to poly-l-glutamine (PGN) enhances the anti-influenza virus activity by orders of magnitude. In this study, we investigated the mechanisms of this phenomenon. Like ZA itself, the...

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Bibliographic Details
Main Authors: Lee, Chia Min (Contributor), Weight, Alisha Kessel (Contributor), Haldar, Jayanta (Contributor), Wang, Ling (Contributor), Klibanov, Alexander M. (Contributor), Chen, Jianzhu (Contributor)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2013-09-26T16:50:50Z.
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