Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Unactivated Alkenes

Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Unactivated Alkenes

One for the Rh(oad): The first rhodium-catalyzed asymmetric intramolecular hydroamination of unactivated olefins was developed by using dialkylbiaryl phosphine ligands (see scheme; cod=1,5-cyclooctadiene, Cy=cyclohexyl). A variety of 2-methylpyrrolidines have been synthesized with high enantioselect...

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Bibliographic Details
Main Authors: Shen, Xiaoqiang (Contributor), Buchwald, Stephen Leffler (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2013-11-01T15:04:16Z.
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Online Access:Get fulltext
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100 1 0 |a Shen, Xiaoqiang  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Chemistry  |e contributor 
100 1 0 |a Shen, Xiaoqiang  |e contributor 
100 1 0 |a Buchwald, Stephen Leffler  |e contributor 
700 1 0 |a Buchwald, Stephen Leffler  |e author 
245 0 0 |a Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Unactivated Alkenes 
260 |b Wiley Blackwell,   |c 2013-11-01T15:04:16Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/81938 
520 |a One for the Rh(oad): The first rhodium-catalyzed asymmetric intramolecular hydroamination of unactivated olefins was developed by using dialkylbiaryl phosphine ligands (see scheme; cod=1,5-cyclooctadiene, Cy=cyclohexyl). A variety of 2-methylpyrrolidines have been synthesized with high enantioselectivities. 
520 |a National Institutes of Health (U.S.) (Grant GM46059) 
520 |a Merck & Co. 
520 |a Boehringer Ingelheim Pharmaceuticals 
520 |a National Institutes of Health (U.S.) (GM 1S10RR13886-01) 
546 |a en_US 
655 7 |a Article 
773 |t Angewandte Chemie International Edition 

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