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01358 am a22002413u 4500 |
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82095 |
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|a dc
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|a Trenkle, James D.
|e author
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|a Massachusetts Institute of Technology. Department of Chemistry
|e contributor
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|a Trenkle, James D.
|e contributor
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|a Jamison, Timothy F.
|e contributor
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|a Jamison, Timothy F.
|e author
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|a Macrocyclization by Nickel-Catalyzed, Ester-Promoted, Epoxide-Alkyne Reductive Coupling: Total Synthesis of (−)-Gloeosporone
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|b Wiley Blackwell,
|c 2013-11-13T14:21:44Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/82095
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|a Ringing the changes: The total synthesis of the title compound centers around a novel strategy that employs a nickel(0)-phosphine complex and triethyl borane in an efficient closure of a 14-membered ring through C--C bond formation (see scheme; cod=cyclooctadiene). The synthesis was accomplished in 10 steps and in approximately 9 % overall yield.
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|a National Institute of General Medical Sciences (U.S.) (GM-72566)
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|a National Science Foundation (U.S.) (CHE-9809061)
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|a National Science Foundation (U.S.) (DBI-9729592)
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|a National Institutes of Health (U.S.) (1S10RR13866-01)
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|a en_US
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|a Article
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|t Angewandte Chemie International Edition
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