Catalytic Addition of Simple Alkenes to Carbonyl Compounds by Use of Group 10 Metals

• Main Authors: Ho, Chun-Yu (Author), Chan, Chun-Wa (Author), Schleicher, Kristin D. (Contributor), Jamison, Timothy F. (Contributor)
• Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
• Format: Article
• Language: English
• Published: Thieme Publishing Group, 2013-11-15T15:25:49Z.
• Subjects: Article
• Online Access: Get fulltext

Recent advances using nickel complexes in the activation of unactivated monosubstituted olefins for catalytic intermolecular carbon-carbon bond-forming reactions with carbonyl compounds, such as simple aldehydes, isocyanates, and conjugated aldehydes and ketones, are discussed. In these reactions, the olefins function as vinyl- and allylmetal equivalents, providing a new strategy for organic synthesis. Current limitations and the outlook for this new strategy are also discussed.
National Institute of General Medical Sciences (U.S.) (GM-063775)
National Institute of General Medical Sciences (U.S.) (GM-072566)
National Science Foundation (U.S.) (CAREER CHE-0134704)
Amgen Inc.
Boehringer Ingelheim Pharmaceuticals
Bristol-Myers Squibb Company
Merck & Co., Inc.
GlaxoSmithKline
Johnson & Johnson
Pfizer Inc.
Alfred P. Sloan Foundation
Wyeth Research
Deshpande Center for Technological Innovation
National Science Foundation (U.S.) (CHE-9809061)
National Science Foundation (U.S.) (DBI-9729592)
National Institutes of Health (U.S.) (1S10RR13886-01)