Polyethylenimine-conjugated gold nanoparticles: Gene transfer potential and low toxicity in the cornea

Polyethylenimine-conjugated gold nanoparticles: Gene transfer potential and low toxicity in the cornea

This study examined the gene transfer efficiency and toxicity of 2-kDa polyethylenimine conjugated to gold nanoparticles (PEI2-GNPs) in the human cornea in vitro and rabbit cornea in vivo. PEI2-GNPs with nitrogen-to-phosphorus ratios of up to 180 exhibited significant transgene delivery in the human...

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Bibliographic Details
Main Authors: Sharma, Ajay (Author), Tandon, Ashish (Author), Tovey, Jonathan C.K (Author), Gupta, Rangan (Author), Robertson, J. David (Author), Fortune, Jennifer A. (Contributor), Klibanov, Alexander M. (Contributor), Cowden, John W. (Author), Rieger, Frank G. (Author), Mohan, Rajiv R. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Elsevier, 2013-11-15T16:55:01Z.
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