Design and Synthesis of a Novel Triptycene-Based Ligand for Modeling Carboxylate-Bridged Diiron Enzyme Active Sites

• Main Authors: Li, Yang (Contributor), Cao, Rui (Contributor), Lippard, Stephen J. (Contributor)
• Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
• Format: Article
• Language: English
• Published: American Chemical Society (ACS), 2013-11-18T13:48:44Z.
• Subjects: Article
• Online Access: Get fulltext

A novel triptycene-based ligand with a preorganized framework was designed to model carboxylate-bridged diiron active sites in bacterial multicomponent monooxygenase (BMM) hydroxylase enzymes. The synthesis of the bis(benzoxazole)-appended ligand L1 depicted was accomplished in 11 steps. Reaction of L1 with iron(II) triflate and a carboxylate source afforded the desired diiron(II) complex [Fe[subscript 2]L1(μ-OH)(μ-O[subscript 2]CAr[superscript Tol])(OTf)[subscript 2]].
National Institute of General Medical Sciences (U.S.) (Grant G032134)