Concise Total Synthesis and Stereochemical Revision of (+)-Naseseazines A and B: Regioselective Arylative Dimerization of Diketopiperazine Alkaloids
Concise and enantioselective total syntheses of (+)-naseseazines A and B are described. Our regioselective and directed dimerization of diketopiperazines provides their critical C3-C[2 over sp] linkages, an assembly with plausible biogenetic relevance. We revise the absolute stereochemistry of (+)-n...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
American Chemical Society (ACS),
2013-11-18T20:26:36Z.
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Online Access: | Get fulltext |
Summary: | Concise and enantioselective total syntheses of (+)-naseseazines A and B are described. Our regioselective and directed dimerization of diketopiperazines provides their critical C3-C[2 over sp] linkages, an assembly with plausible biogenetic relevance. We revise the absolute stereochemistry of (+)-naseseazines A and B. National Institute of General Medical Sciences (U.S.) (GM089732) Amgen Inc. DuPont (Firm) American Society for Engineering Education. National Defense Science and Engineering Graduate Fellowship |
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