ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling
A Disintegrin and Metalloproteinases (ADAMs) are the principal enzymes for shedding receptor tyrosine kinase (RTK) ectodomains and ligands from the cell surface. Multiple layers of activity regulation, feedback, and catalytic promiscuity impede our understanding of context-dependent ADAM "shedd...
Main Authors: | Miller, Miles Aaron (Contributor), Meyer, Aaron Samuel (Contributor), Beste, Michael T. (Contributor), Lasisi, Zainab A. (Contributor), Reddy, Sonika N. (Contributor), Jeng, Karen (Contributor), Griffith, Linda G. (Contributor), Lauffenburger, Douglas A. (Contributor), Chen, Chia-Hung (Author), Han, Jongyoon (Author), Isaacson, Keith B. (Author) |
---|---|
Other Authors: | Massachusetts Institute of Technology. Center for Gynepathology Research (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor) |
Format: | Article |
Language: | English |
Published: |
National Academy of Sciences (U.S.),
2013-12-30T18:34:02Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain
by: Miller, Miles Aaron, et al.
Published: (2015) -
NKG2D Ligand Shedding in Response to Stress: Role of ADAM10
by: Alessandra Zingoni, et al.
Published: (2020-03-01) -
Multiplexed Protease Activity Assay for Low-Volume Clinical Samples Using Droplet-Based Microfluidics and Its Application to Endometriosis
by: Chen, Chia-Hung, et al.
Published: (2014) -
LRP1 shedding in human brain: roles of ADAM10 and ADAM17
by: Reiss Karina, et al.
Published: (2009-04-01) -
Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways
by: Dang, Michelle, et al.
Published: (2014)