Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9
TLR9 recognizes unmethylated CpG-containing DNA commonly found in bacteria. Synthetic oligonucleotides containing CpG-motifs (CpG ODNs) recapitulate the activation of TLR9 by microbial DNA, whereas inversion of the CG dinucleotide within the CpG motif to GC (GpC ODNs) renders such ODNs inactive. Thi...
| Main Authors: | , |
|---|---|
| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Wiley Blackwell,
2014-02-18T20:23:33Z.
|
| Subjects: | |
| Online Access: | Get fulltext |