Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9
TLR9 recognizes unmethylated CpG-containing DNA commonly found in bacteria. Synthetic oligonucleotides containing CpG-motifs (CpG ODNs) recapitulate the activation of TLR9 by microbial DNA, whereas inversion of the CG dinucleotide within the CpG motif to GC (GpC ODNs) renders such ODNs inactive. Thi...
Main Authors: | Avalos, Ana M. (Author), Ploegh, Hidde (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor) |
Format: | Article |
Language: | English |
Published: |
Wiley Blackwell,
2014-02-18T20:23:33Z.
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Subjects: | |
Online Access: | Get fulltext |
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