Contributions of a disulfide bond and a reduced cysteine side chain to the intrinsic activity of the HDL receptor SR-BI

Contributions of a disulfide bond and a reduced cysteine side chain to the intrinsic activity of the HDL receptor SR-BI

The high density lipoprotein (HDL) receptor, scavenger receptor class B, type I (SR-BI), binds HDL and mediates selective cholesteryl ester uptake. SR-BI's structure and mechanism are poorly understood. We used mass spectrometry to assign the two disulfide bonds in SR-BI that connect cysteines...

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Bibliographic Details
Main Authors: Yu, Miao (Contributor), Lau, Thomas Y. (Author), Krieger, Monty (Contributor), Carr, Steven A (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Carr, Steven A. (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2014-04-07T17:16:10Z.
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