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01771 am a22003133u 4500 |
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86182 |
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|a dc
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|a Sainlos, Matthieu
|e author
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|a Massachusetts Institute of Technology. Department of Biology
|e contributor
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|a Massachusetts Institute of Technology. Department of Chemistry
|e contributor
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|a Imperiali, Barbara
|e contributor
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|a Imperiali, Barbara
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|a Sainlos, Matthieu
|e contributor
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|a Iskenderian, Wendy S.
|e contributor
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|a Olivier, Nelson B.
|e contributor
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|a Iskenderian, Wendy S.
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|a Olivier, Nelson B.
|e author
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|a Choquet, Daniel
|e author
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|a Imperiali, Barbara
|e author
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|a Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions
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|b American Chemical Society,
|c 2014-04-16T16:21:17Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/86182
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|a We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate binding determinant of the motif. The strategy was implemented and validated for both simple monovalent and biomimetic divalent ligands, which have recently been established as powerful tools for acute perturbation of native PDZ domain-dependent interactions in live cells.
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|a National Science Foundation (U.S.) (NSF CHE-0414243)
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|a European Commission (Marie Curie Postdoctoral Fellowship (PICK-CPP))
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|a France. Agence nationale de la recherche
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|a en_US
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|a Article
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|t Journal of the American Chemical Society
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