Tryptophan Cluster Protects Human γD-Crystallin from Ultraviolet Radiation-Induced Photoaggregation
Exposure to ultraviolet radiation (UVR) is a significant risk factor for age-related cataract, a disease of the human lens and the most prevalent cause of blindness in the world. Cataract pathology involves protein misfolding and aggregation of the primary proteins of the lens, the crystallins. Huma...
Main Authors: | Schafheimer, Steven Nathaniel (Contributor), King, Jonathan Alan (Contributor) |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor) |
Format: | Article |
Language: | English |
Published: |
John Wiley & Sons, Inc,
2014-06-30T19:47:56Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Tyrosine/Cysteine Cluster Sensitizing Human γD-Crystallin to Ultraviolet Radiation-Induced Photoaggregation in Vitro
by: Schafheimer, Steven Nathaniel, et al.
Published: (2015) -
Ultraviolet radiation-induced aggregation of human lens protein [g̳a̳m̳m̳a̳]D-crystallin : characterization of the protective tryptophan clusters and key sensitizing residues
by: Schafheimer, Nathaniel (Steven Nathaniel)
Published: (2014) -
Mechanism of the Very Efficient Quenching of Tryptophan Fluorescence in Human γD- and γS-Crystallins: The γ-Crystallin Fold May Have Evolved To Protect Tryptophan Residues from Ultraviolet Photodamage
by: Callis, Patrik R., et al.
Published: (2012) -
Mechanism of the Efficient Tryptophan Fluorescence Quenching in Human γD-Crystallin Studied by Time-Resolved Fluorescence
by: Chen, Jiejin, et al.
Published: (2012) -
UV-radiation Induced Disruption of Dry-Cavities in Human γD-crystallin Results in Decreased Stability and Faster Unfolding
by: Xia, Zhen, et al.
Published: (2014)