Dual Responsiveness of a Tunable Thermosensitive Polypeptide

The temperature- and pH-dependent solubility of poly(γ-propargyl l-glutamate) (PPLG) functionalized through a copper-catalyzed 1,3-cycloaddition reaction between an alkyne and an azide can be tuned with precision over a broad range of conditions by varying the ratio of substitution of short oligo(et...

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Bibliographic Details
Main Authors: Chopko Ahrens, Caroline (Contributor), Lowden, Erika L. (Contributor), Engler, Amanda C. (Contributor), Griffith, Linda G. (Contributor), Hammond, Paula T. (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Gynepathology Research (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2014-09-04T16:25:26Z.
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Online Access:Get fulltext
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100 1 0 |a Chopko Ahrens, Caroline  |e author 
100 1 0 |a Massachusetts Institute of Technology. Center for Gynepathology Research  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Biological Engineering  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Chemical Engineering  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Mechanical Engineering  |e contributor 
100 1 0 |a Chopko Ahrens, Caroline  |e contributor 
100 1 0 |a Lowden, Erika L.  |e contributor 
100 1 0 |a Engler, Amanda C.  |e contributor 
100 1 0 |a Griffith, Linda G.  |e contributor 
100 1 0 |a Hammond, Paula T.  |e contributor 
700 1 0 |a Lowden, Erika L.  |e author 
700 1 0 |a Engler, Amanda C.  |e author 
700 1 0 |a Griffith, Linda G.  |e author 
700 1 0 |a Hammond, Paula T.  |e author 
245 0 0 |a Dual Responsiveness of a Tunable Thermosensitive Polypeptide 
260 |b American Chemical Society (ACS),   |c 2014-09-04T16:25:26Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/89174 
520 |a The temperature- and pH-dependent solubility of poly(γ-propargyl l-glutamate) (PPLG) functionalized through a copper-catalyzed 1,3-cycloaddition reaction between an alkyne and an azide can be tuned with precision over a broad range of conditions by varying the ratio of substitution of short oligo(ethylene glycol) and diisopropylamine side groups. 
520 |a National Institutes of Health (U.S.) (NIH Biomechanics Training Grant) 
520 |a National Institutes of Health (U.S.) (NIH R01 EB010246-03) 
520 |a National Science Foundation (U.S.) (NSF DMR Grant Number 0705234) 
520 |a National Institutes of Health (U.S.) (grant U54-CA112967) 
520 |a United States. Environmental Protection Agency (EPA STAR fellowship) 
546 |a en_US 
655 7 |a Article 
773 |t ACS Macro Letters