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02564 am a22004093u 4500 |
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|a dc
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|a Mizrahi, Boaz
|e author
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|a Harvard University-
|e contributor
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|a Massachusetts Institute of Technology. Department of Chemical Engineering
|e contributor
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|a Koch Institute for Integrative Cancer Research at MIT
|e contributor
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|a Mizrahi, Boaz
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|a Shankarappa, Sahadev A.
|e contributor
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|a Timko, Brian P.
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|a Whitehead, Kathryn Ann
|e contributor
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|a Lee, Jung-Jae
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|a Langer, Robert
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|a Anderson, Daniel Griffith
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|a Shankarappa, Sahadev A.
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|a Hickey, Julia M.
|e author
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|a Dohlman, Jenny C.
|e author
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|a Timko, Brian P.
|e author
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|a Whitehead, Kathryn Ann
|e author
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|a Lee, Jung-Jae
|e author
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|a Anderson, Daniel Griffith
|e author
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|a Kohane, Daniel S.
|e author
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|a Langer, Robert S
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|a A Stiff Injectable Biodegradable Elastomer
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|b Wiley-VCH Verlag GmbH & Co.,
|c 2014-10-29T20:51:53Z.
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| 856 |
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|z Get fulltext
|u http://hdl.handle.net/1721.1/91235
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|a Injectable materials often have shortcomings in mechanical and drug-eluting properties that are attributable to their high water contents. A water-free, liquid four-armed PEG modified with dopamine end groups is described which changes from liquid to elastic solid by reaction with a small volume of Fe3+ solution. The elastic modulus and degradation times increase with increasing Fe3+ concentrations. Both the free base and the water-soluble form of lidocaine can be dissolved in the PEG4-dopamine and released in a sustained manner from the cross-linked matrix. PEG4-dopamine is retained in the subcutaneous space in vivo for up to 3 weeks with minimal inflammation. This material's tailorable mechanical properties, biocompatibility, ability to incorporate hydrophilic and hydrophobic drugs and release them slowly are desirable traits for drug delivery and other biomedical applications.
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|a National Institute on Deafness and Other Communication Disorders (U.S.) (NIDCD R21 DC 009986)
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|a National Institutes of Health (U.S.) (NIH Ruth L. Kirschstein National Research Service Award (no. F32GM096546))
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|a National Institutes of Health (U.S.) (NIH R01 EB00244)
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|a en_US
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|a Article
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| 773 |
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|t Advanced Functional Materials
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