Clioquinol promotes the degradation of metal-dependent amyloid-β  (Aβ) oligomers to restore endocytosis and ameliorate Aβ  toxicity

Clioquinol promotes the degradation of metal-dependent amyloid-β  (Aβ) oligomers to restore endocytosis and ameliorate Aβ  toxicity

Alzheimer's disease (AD) is a common, progressive neurodegenerative disorder without effective disease-modifying therapies. The accumulation of amyloid-β peptide (Aβ) is associated with AD. However, identifying new compounds that antagonize the underlying cellular pathologies caused by Aβ has b...

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Bibliographic Details
Main Authors: Matlack, Kent E. S. (Author), Tardiff, Daniel F. (Author), Narayan, Priyanka (Author), Hamamichi, Shusei (Author), Caldwell, Kim A. (Author), Caldwell, Guy A. (Author), Lindquist, Susan (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2014-11-12T14:06:27Z.
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