Steady States and Dynamics of Urokinase-Mediated Plasmin Activation In Silico and In Vitro

Steady States and Dynamics of Urokinase-Mediated Plasmin Activation In Silico and In Vitro

Plasmin (PLS) and urokinase-type plasminogen activator (UPA) are ubiquitous proteases that regulate the extracellular environment. Although they are secreted in inactive forms, they can activate each other through proteolytic cleavage. This mutual interplay creates the potential for complex dynamics...

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Bibliographic Details
Main Authors: Venkatraman, Lakshmi (Author), Li, Huipeng (Author), Dewey, C. Forbes (Contributor), White, Jacob K (Author), Bhowmick, Sourav S. (Author), Yu, Hanry (Author), Tucker-Kellogg, Lisa (Author), White, Jacob K. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-12-08T17:27:04Z.
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