Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo
Autophagy is of increasing interest as a target for cancer therapy. We find that leucine deprivation causes the caspase-dependent apoptotic death of melanoma cells because it fails to appropriately activate autophagy. Hyperactivation of the RAS-MEK pathway, which is common in melanoma, prevents leuc...
Main Authors: | Sheen, Joon-Ho (Author), Zoncu, Roberto (Author), Kim, Dohoon (Author), Sabatini, David M (Author), Sabatini, David (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor) |
Format: | Article |
Language: | English |
Published: |
Elsevier,
2014-12-10T17:10:53Z.
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Subjects: | |
Online Access: | Get fulltext |
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