Intratumor heterogeneity alters most effective drugs in designed combinations

Intratumor heterogeneity alters most effective drugs in designed combinations

The substantial spatial and temporal heterogeneity observed in patient tumors poses considerable challenges for the design of effective drug combinations with predictable outcomes. Currently, the implications of tissue heterogeneity and sampling bias during diagnosis are unclear for selection and su...

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Bibliographic Details
Main Authors: Zhao, Boyang (Contributor), Hemann, Michael (Contributor), Lauffenburger, Douglas A (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Lauffenburger, Douglas A. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2015-02-04T20:40:15Z.
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