|
|
|
|
| LEADER |
01563 am a22003133u 4500 |
| 001 |
95474 |
| 042 |
|
|
|a dc
|
| 100 |
1 |
0 |
|a Wisnovsky, Simon P.
|e author
|
| 100 |
1 |
0 |
|a Massachusetts Institute of Technology. Department of Chemistry
|e contributor
|
| 100 |
1 |
0 |
|a Wilson, Justin J.
|e contributor
|
| 100 |
1 |
0 |
|a Radford, Robert J.
|e contributor
|
| 100 |
1 |
0 |
|a Chan, Maria R.
|e contributor
|
| 100 |
1 |
0 |
|a Lippard, Stephen J.
|e contributor
|
| 700 |
1 |
0 |
|a Wilson, Justin J.
|e author
|
| 700 |
1 |
0 |
|a Radford, Robert J.
|e author
|
| 700 |
1 |
0 |
|a Pereira, Mark P.
|e author
|
| 700 |
1 |
0 |
|a Chan, Maria R.
|e author
|
| 700 |
1 |
0 |
|a Laposa, Rebecca R.
|e author
|
| 700 |
1 |
0 |
|a Lippard, Stephen J.
|e author
|
| 700 |
1 |
0 |
|a Kelley, Shana O.
|e author
|
| 245 |
0 |
0 |
|a Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent
|
| 260 |
|
|
|b Elsevier,
|c 2015-02-24T15:31:09Z.
|
| 856 |
|
|
|z Get fulltext
|u http://hdl.handle.net/1721.1/95474
|
| 520 |
|
|
|a An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemotherapeutic. This study demonstrates the specific delivery of a platinum drug to mitochondria and investigates the effects of directing this agent outside the nucleus.
|
| 520 |
|
|
|a National Cancer Institute (U.S.) (Grant CA034992)
|
| 520 |
|
|
|a David H. Koch Graduate Fellowship
|
| 546 |
|
|
|a en_US
|
| 655 |
7 |
|
|a Article
|
| 773 |
|
|
|t Chemistry and Biology
|
