Convergent diversity-oriented side-chain macrocyclization scan for unprotected polypeptides

Convergent diversity-oriented side-chain macrocyclization scan for unprotected polypeptides

Here we describe a general synthetic platform for side-chain macrocyclization of an unprotected peptide library based on the S[subscript N]Ar reaction between cysteine thiolates and a new generation of highly reactive perfluoroaromatic small molecule linkers. This strategy enabled us to simultaneous...

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Bibliographic Details
Main Authors: Zou, Yekui (Contributor), Spokoyny, Alexander M. (Contributor), Zhang, Chi (Contributor), Yu, Hongtao (Author), Lin, Yu-Shan (Author), Pentelute, Bradley L. (Contributor), Simon, Mark (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Royal Society of Chemistry, The, 2015-02-25T19:59:34Z.
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