Enzymatic "Click" Ligation: Selective Cysteine Modification in Polypeptides Enabled by Promiscuous Glutathione S-Transferase

Enzymatic "Click" Ligation: Selective Cysteine Modification in Polypeptides Enabled by Promiscuous Glutathione S-Transferase

Singled out for special treatment: Naturally occurring glutathione S-transferase (GST) was used to catalyze an efficient "click" ligation between polypeptides with an N-terminal glutathione sequence and biomolecules or chemical probes containing perfluorinated aromatic groups (see scheme)....

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Bibliographic Details
Main Authors: Zhang, Chi (Contributor), Spokoyny, Alexander M. (Contributor), Zou, Yekui (Contributor), Pentelute, Bradley L. (Contributor), Simon, Mark (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2015-02-25T20:15:29Z.
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