Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

Activation of Ras proteins underlies functional decisions in diverse cell types. Two molecules, RasGRP and SOS, catalyze Ras activation in lymphocytes. Binding of active Ras to SOS' allosteric pocket markedly increases SOS' activity establishing a positive feedback loop for SOS-mediated Ra...

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Main Authors: Das, Jayajit (Contributor), Ho, Mary (Author), Zikherman, Julie (Author), Govern, Christopher C. (Contributor), Yang, Ming (Contributor), Weiss, Arthur (Author), Chakraborty, Arup K. (Contributor), Roose, Jeroen P. (Author)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-03-25T18:48:24Z.
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