Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress
Oxidative protein folding in the endoplasmic reticulum (ER) has emerged as a potentially significant source of cellular reactive oxygen species (ROS). Recent studies suggest that levels of ROS generated as a byproduct of oxidative folding rival those produced by mitochondrial respiration. Mechanisms...
Main Authors: | Pareja, Kristeen A (Author), Sevier, Carolyn S (Author), Kaiser, Chris (Contributor), Wang, Jie, S.M. Massachusetts Institute of Technology (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor) |
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications, Ltd.,
2015-04-10T17:50:33Z.
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Subjects: | |
Online Access: | Get fulltext |
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