Simple battery armor to protect against gastrointestinal injury from accidental ingestion

Inadvertent battery ingestion in children and the associated morbidity and mortality results in thousands of emergency room visits every year. Given the risk for serious electrochemical burns within hours of ingestion, the current standard of care for the treatment of batteries in the esophagus is e...

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Bibliographic Details
Main Authors: Laulicht, Bryan E. (Contributor), Deshpande, Vikram (Author), Karp, Jeffrey Michael (Contributor), Langer, Robert S (Author), Traverso, Carlo Giovanni (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Traverso, Gio (Contributor), Langer, Robert (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2015-05-04T15:30:46Z.
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Online Access:Get fulltext
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042 |a dc 
100 1 0 |a Laulicht, Bryan E.  |e author 
100 1 0 |a Harvard University-  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Chemical Engineering  |e contributor 
100 1 0 |a Koch Institute for Integrative Cancer Research at MIT  |e contributor 
100 1 0 |a Laulicht, Bryan E.  |e contributor 
100 1 0 |a Traverso, Gio  |e contributor 
100 1 0 |a Langer, Robert  |e contributor 
100 1 0 |a Karp, Jeffrey Michael  |e contributor 
700 1 0 |a Deshpande, Vikram  |e author 
700 1 0 |a Karp, Jeffrey Michael  |e author 
700 1 0 |a Langer, Robert S  |e author 
700 1 0 |a Traverso, Carlo Giovanni  |e author 
245 0 0 |a Simple battery armor to protect against gastrointestinal injury from accidental ingestion 
260 |b National Academy of Sciences (U.S.),   |c 2015-05-04T15:30:46Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/96898 
520 |a Inadvertent battery ingestion in children and the associated morbidity and mortality results in thousands of emergency room visits every year. Given the risk for serious electrochemical burns within hours of ingestion, the current standard of care for the treatment of batteries in the esophagus is emergent endoscopic removal. Safety standards now regulate locked battery compartments in toys, which have resulted in a modest reduction in inadvertent battery ingestion; specifically, 3,461 ingestions were reported in 2009, and 3,366 in 2013. Aside from legislation, minimal technological development has taken place at the level of the battery to limit injury. We have constructed a waterproof, pressure-sensitive coating, harnessing a commercially available quantum tunneling composite. Quantum tunneling composite coated (QTCC) batteries are nonconductive in the low-pressure gastrointestinal environment yet conduct within the higher pressure of standard battery housings. Importantly, this coating technology enables most battery-operated equipment to be powered without modification. If these new batteries are swallowed, they limit the external electrolytic currents responsible for tissue injury. We demonstrate in a large-animal model a significant decrease in tissue injury with QTCC batteries compared with uncoated control batteries. In summary, here we describe a facile approach to increasing the safety of batteries by minimizing the risk for electrochemical burn if the batteries are inadvertently ingested, without the need for modification of most battery-powered devices. 
520 |a National Institutes of Health (U.S.) (Grant DE013023) 
520 |a National Institutes of Health (U.S.) (Grant EB000244) 
520 |a National Institutes of Health (U.S.) (Grant GM086433) 
520 |a National Institutes of Health (U.S.) (Grant T32 DK 7191-38) 
546 |a en_US 
655 7 |a Article 
773 |t Proceedings of the National Academy of Sciences