Trade-offs between retroactivity and noise in connected transcriptional components
At the interconnection of two gene transcriptional components in a biomolecular network, the noise in the downstream component can be reduced by increasing its gene copy number. However, this method of reducing noise increases the load applied to the upstream system, called retroactivity, thereby ca...
Main Authors: | Del Vecchio, Domitilla (Contributor), Herath, Narmada K. (Contributor) |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor) |
Format: | Article |
Language: | English |
Published: |
2015-06-15T16:02:04Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Retroactivity to the input in complex gene transcription networks
by: Gyoergy, Andras, et al.
Published: (2018) -
Retroactivity Controls the Temporal Dynamics of Gene Transcription
by: Jayanthi, Shridhar, et al.
Published: (2018) -
Stochastic Analysis of Retroactivity in Transcriptional Networks through Singular Perturbation
by: Ghaemi, Reza, et al.
Published: (2013) -
Model order reduction for Linear Noise Approximation using time-scale separation
by: Herath, Narmada K, et al.
Published: (2018) -
Reduced Linear Noise Approximation for Biochemical Reaction Networks with Time-Scale Separation: The Stochastic tQSSA⁺
by: Herath, Narmada K, et al.
Published: (2018)