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|a dc
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|a Li, Lele
|e author
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|a Massachusetts Institute of Technology. Department of Chemical Engineering
|e contributor
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|a Koch Institute for Integrative Cancer Research at MIT
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|a Li, Lele
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|a Tong, Rong
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|a Chu, Hunghao
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|a Wang, Weiping
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|a Langer, Robert
|e contributor
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|a Tong, Rong
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|a Chu, Hunghao
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|a Wang, Weiping
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|a Kohane, Daniel S.
|e author
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|a Langer, Robert S
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|a Aptamer photoregulation in vivo
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|b National Academy of Sciences (U.S.),
|c 2015-06-15T18:50:58Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/97435
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|a The in vivo application of aptamers as therapeutics could be improved by enhancing target-specific accumulation while minimizing off-target uptake. We designed a light-triggered system that permits spatiotemporal regulation of aptamer activity in vitro and in vivo. Cell binding by the aptamer was prevented by hybridizing the aptamer to a photo-labile complementary oligonucleotide. Upon irradiation at the tumor site, the aptamer was liberated, leading to prolonged intratumoral retention. The relative distribution of the aptamer to the liver and kidney was also significantly decreased, compared to that of the free aptamer.
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|a National Institutes of Health (U.S.) (Grant GM073626)
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|a en_US
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|a Article
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|t Proceedings of the National Academy of Sciences
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