Aptamer photoregulation in vivo

Aptamer photoregulation in vivo

The in vivo application of aptamers as therapeutics could be improved by enhancing target-specific accumulation while minimizing off-target uptake. We designed a light-triggered system that permits spatiotemporal regulation of aptamer activity in vitro and in vivo. Cell binding by the aptamer was pr...

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Bibliographic Details
Main Authors: Li, Lele (Contributor), Tong, Rong (Contributor), Chu, Hunghao (Contributor), Wang, Weiping (Contributor), Kohane, Daniel S. (Author), Langer, Robert S (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Langer, Robert (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2015-06-15T18:50:58Z.
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