PEG-Polypeptide Block Copolymers as pH-Responsive Endosome-Solubilizing Drug Nanocarriers

PEG-Polypeptide Block Copolymers as pH-Responsive Endosome-Solubilizing Drug Nanocarriers

Herein we report the potential of click chemistry-modified polypeptide-based block copolymers for the facile fabrication of pH-sensitive nanoscale drug delivery systems. PEG-polypeptide copolymers with pendant amine chains were synthesized by combining N-carboxyanhydride-based ring-opening polymeriz...

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Bibliographic Details
Main Authors: Morton, Stephen Winford (Contributor), Deng, Zhou J. (Contributor), Murphy, Ryan P. (Author), Epps, Thomas H. (Author), Quadir, Mohiuddin Abdul (Contributor), Shopsowitz, Kevin (Contributor), Hammond, Paula T (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Hammond, Paula T. (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2015-06-22T15:14:00Z.
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